The campus consists of a girls high school for years 7−12 and a coeducational junior school for years K−6, sporting grounds, and boarding facilities for 137 students. The college has strong ties with Mazenod College where many male students attending St Brigid's Primary School continue their education.
St Brigid's College was founded in 1929 by the Sisters of Mercy as an extension of the West Perth convent and college also named after Saint Brigid of Kildare. Construction of the buildings commenced in 1913 for Archibald and Maude Sanderson, and were used as a private day and boarding school for approximately 20 students.
In 1919, at the end of World War I, the buildings were sold to the Red Cross to be rented to the Repatriation Department to house sick and wounded soldiers. During this period the building was completed and oak trees from Windsor Castle were planted in the grounds.